03/09/2012
Chromatin and Pluripotency:the MYSTerious Connection .Kloc A Ivanova N.Cell Stem Cell. August 2012
Although histone acetylation is critical for maintaining embryonic stem cell pluripotency, the molecular machinery involved remains poorly understood. Li et al. (2012) now show that Mof, a MYST family histone acetyltransferase, functions as a coactivator of Nanog-mediated transcription, maintains the expression of pluripotency-associated genes, and primes developmental genes for differentiation.
