Investigaciones expone trabajos que pueden aún no tener evidencias suficientes por su actualidad.

Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability

Por: Ji Young Park, Jung Wook Yun, Young Whan Choi, Jin Ung Bae, Kyo Won Seo, Seung Jin Lee, So Youn Park, Ki Whan Hong y Chi Dae Kim. Hypertension Research (2012) 35, 928–934.

These alterations in BP, NOS phosphorylation and ROS production in the vasculature of Ang II-treated mice were markedly and dose-dependently reversed by simultaneous administration of GA (2 and 10μg kg−1 per min). In addition, Ang II-induced ROS production in cultured vascular cells such as endothelial cells and vascular smooth muscle cells was markedly attenuated by GA. These results suggested that GA attenuated the increase in BP via preservation of vascular NO bioavailability not only by inhibiting ROS production but also by preventing the impairment of eNOS function in the vasculature of Ang II-induced hypertensive mice.

Investigaciones expone trabajos que pueden aún no tener evidencias suficientes por su actualidad.

Association of the antihypertensive response of iptakalim with KCNJ11 (Kir6.2 gene) polymorphisms in Chinese Han hypertensive patients.

Por: Rui-feng Duan, Wen-yu Cui y Hai Wang.  Acta Pharmacologica Sinica (2011) 32: 1078–1084.

To study the relationship between the antihypertensive response of iptakalim and KCNJ11 polymorphisms in Chinese Han hypertensive patients.
Four common A190A, E23K, I337V and 3′UTR +62 G/A polymorphisms were found in KCNJ11. The E23K, I337V and 3′UTR +62 G/A polymorphisms were in complete linkage disequilibrium, and I337V was used as a representative.
The results suggest the KCNJ11 polymorphisms are associated with the SBP-lowering response of short-term iptakalim therapy in Chinese Han hypertensive patients.