Brain renin–angiotensin system in the nexus of hypertension and aging
Por: Amy C Arnold, Patricia E Gallagher y Debra I Diz. Hypertension Research (2013) 36, 5–13
Aging is associated with an imbalance in sympathetic and parasympathetic outflow to cardiovascular effector organs.
This autonomic imbalance contributes to the decline in cardiovagal baroreceptor reflex function during aging, which allows for unrestrained activation of the sympathetic nervous system to negatively impact resting systolic blood pressure and its variability. Further, impaired baroreflex function can contribute to the development of insulin resistance and other features of the metabolic syndrome during aging through overlap in autonomic neural pathways that regulate both cardiovascular and metabolic functions. [publicada: 23 de enero de enero 2013]
Por: Graudal Niels Albert, Hubeck-Graudal Thorbjorn y Jurgens Gesche. Cochrane Database of Systematic Reviews. The Cochrane Library, 2011, Issue 11, Art. No. CD004022.
In spite of more than 100 years of investigations the question of reduced sodium intake as a health prophylaxis initiative is still unsolved. To estimate the effects of low sodium versus high sodium intake on systolic and diastolic blood pressure (SBP and DBP), plasma or serum levels of renin, aldosterone, catecholamines, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides. [publicada: 11 de diciembre 2012].
Por: Q Chen1, S Turban, E R Miller y L J Appel. Journal of Human Hypertension (2012) 26, 664–669.
A diet rich in fruits, vegetables and low-fat dairy products, and reduced in saturated fat, total fat and cholesterol (the ‘DASH’ diet) significantly lowers blood pressure (BP). Previous studies have documented that certain therapies that lower BP increase plasma renin activity (PRA). Using data from the Dietary Approaches to Stop Hypertension (DASH) trial, we assessed the effects of dietary patterns on PRA and determined the relationship of change in PRA with change in BP on each diet. After eating a control diet for 3 weeks, participants were then randomized to receive for 8 weeks: the control diet, a diet rich in fruits and vegetables (F/V), or the DASH diet. Baseline and follow-up levels of PRA were available in 381 participants. (publicado: 05–11-2012)
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