15/03/2013

Hypertension: Should thiazides be used for hypertension in obese patients?

mar 15th, 2013. En: Propuestas del editor.

Por: Susan J. Allison. Nature Reviews Cardiology 10, 62 (February 2013).

Previous studies of hypertensive patients at high risk of cardiovascular events have reported paradoxically higher event rates in normal-weight patients than in obese individuals. A subanalysis of ACCOMPLISH trial data suggests that this paradox might reflect the differential effects of antihypertensive treatment types, rather than the effect of body size, per se.
The ACCOMPLISH trial aimed to compare the effects of benazepril plus amlodipine versus benazepril plus a thiazide diuretic (hydrochlorothiazide) in hypertensive patients at high risk of cardiovascular events. As a prespecified subanalysis, Michael Weber and colleagues have now assessed patient outcomes on the basis of BMI, by categorizing participants as either obese (BMI ≥30 kg/m2; n = 5,709), overweight (BMI ≥25 to <30 kg/m2; n = 4,157) or normal weight (BMI <25 kg/m2; n = 1,616). [Actualizado: 15 de marzo 2013].