A Possible Interaction Between Systemic and Renal Angiotensinogen in the Control of Blood Pressure
Por: Nirupama Ramkumar, Deborah Stuart, Jian Ying y Donald E. Kohan. American Journal of Hypertension, Volume 26, Issue 4, Pp. 473-480.
Angiotensinogen (AGT) is synthesized in the liver and proximal tubule. AGT overexpression at either site might increase blood pressure (BP). We used transgenic mice with AGT overexpression in proximal tubule (K), liver (L), or both sites (KL) to determine the relative contributions of hepatic- and proximal tubule–derived AGT in modulating BP. Mice with liver AGT overexpression manifest salt-sensitive hypertension, whereas mice with renal AGT overexpression are hypertensive regardless of salt intake. Systemic AGT may stimulate endogenous renal AGT synthesis during high sodium intake, leading to hypertension in L mice. [Actualizado: 3 de junio 2013]
Estudios importantes sobre hipertension arterial de Cuba y el mundo
Por: Mónica Doménech, Antonio Berruezo, Irma Molina, Lluis Mont y Antonio Coca. Rev Esp Cardiol. 2013;66:458-63. – Vol. 66 Núm.06.
La hipertensión es un factor de riesgo de fibrilación auricular. Parece que la activación del sistema renina-angiotensina interviene en el crecimiento auricular con la liberación de los péptidos natriuréticos auricular y cerebral. El objetivo de este estudio es evaluar la relación de la presión arterial ambulatoria y los valores de péptidos natriuréticos con el tamaño auricular izquierdo en sujetos normotensos con fibrilación auricular idiopática. La presión arterial nocturna se asocia al tamaño auricular izquierdo y la liberación de péptidos natriuréticos en los pacientes normotensos con fibrilación auricular idiopática. [Actualizado: 5 de junio 2013].
Antihypertensive drug therapy for mild to moderate hypertension during pregnancy (Review)
Por: Abalos E, Duley L, Steyn DW y Henderson-Smart DJ. The Cochrane Collaboration. 2012, Issue 10. (Cochrane Database of Systematic Reviews 2007, Issue 1. Art. No.: CD002252.).
Mild to moderate hypertension during pregnancy is common. Antihypertensive drugs are often used in the belief that lowering blood pressure will prevent progression to more severe disease, and thereby improve. To assess the effects of antihypertensive drug treatments for women with mild to moderate hypertension during pregnancy outcome. It remains unclear whether antihypertensive drug therapy for mild to moderate hypertension during pregnancy is worthwhile.
Whether the reduction in the risk of severe hypertension is considered sufficient to warrant treatment is a decision that should be made by women in consultation with their obstetrician. If an antihypertensive is used, there is insufficient evidence to conclude that one antihypertensive is better than another.The choice should therefore depend on the previous experience of the clinician and the woman’s preference. [Actualizado: 5 de junio 2013].
Vitamin D, a new antihypertensive hormone?
Por: Leon F. Ferder. Rev Fed Arg Cardiol. 2013; 42(1): 15-19.
Humanityis facing apandemicof vitamin D deficiency that affectsn early 50% of the world population, which would bethe expression of a high pro inflammatory response of the population to cultural evolutionary changes. Low levels of Vitamin Dare associated with higher markers of inflammation and higher level sof RAS, causing hypertension, left ventricular hypertrophy, renal protectionfailure against hyperglycemia and atherosclerosis. Several controlled clinical trials and meta-analysis of randomized trials of supplementation with moderate and high doses of vitamin Dshowed mixed results in reducing mortality or cardiovascular riskin relation to vitamin D status. [Actualizado: 5 de junio 2013]
Drugs and Orthostatic Hypotension: Evidence from Literature
Por: Valeria Milazzo, Cristina Di Stefano, Serena Servo, Valentina Crudo, Chiara Fulcheri, Simona Maule y Franco Veglio. Journal of Hypertension: Open Access, J Hypertens 2012, 1:2.
Orthostatic hypotension is defined as the reduction of systolic blood pressure of at least 20 mmHg or the dropping of diastolic blood pressure of at least 10 mmHg within 3 minutes of standing compared to baseline values. It can be divided into neurogenic and non neurogenic forms. Neurogenic forms are caused by a primitive damage to autonomic nervous system, while drugs are the most common cause of non neurogenic orthostatic hypotension; they may also complicate or aggravate neurogenic forms.
Many drugs can determine orthostatic hypotension, including both cardiovascular drugs and therapies used for neurological and psychiatric disorders. This effect is furthermore enhanced by multiple pharmacological treatments. It is important for the clinician to know the potential hazard of orthostatic hypotension, in order to avoid syncope, falls, hypoperfusion symptoms, excess of mortality and loss of compliance to treatment. [Actualizado: 5 de junio 2013]
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