Association of the antihypertensive response of iptakalim with KCNJ11 (Kir6.2 gene) polymorphisms in Chinese Han hypertensive patients.

Investigaciones expone trabajos que pueden aún no tener evidencias suficientes por su actualidad.

Association of the antihypertensive response of iptakalim with KCNJ11 (Kir6.2 gene) polymorphisms in Chinese Han hypertensive patients.

Por: Rui-feng Duan, Wen-yu Cui y Hai Wang.  Acta Pharmacologica Sinica (2011) 32: 1078–1084.

To study the relationship between the antihypertensive response of iptakalim and KCNJ11 polymorphisms in Chinese Han hypertensive patients.
Four common A190A, E23K, I337V and 3′UTR +62 G/A polymorphisms were found in KCNJ11. The E23K, I337V and 3′UTR +62 G/A polymorphisms were in complete linkage disequilibrium, and I337V was used as a representative.
The results suggest the KCNJ11 polymorphisms are associated with the SBP-lowering response of short-term iptakalim therapy in Chinese Han hypertensive patients.