Association between chlorthalidone treatment of systolic hypertension and long-term survival.

Association between chlorthalidone treatment of systolic hypertension and long-term survival.

Por: Kostis JB, Cabrera J, Cheng JQ, Cosgrove NM, Deng Y, Pressel SL, y Davis BR.  JAMA. 2011 Dec 21;306(23):2588-93.

In the Systolic Hypertension in the Elderly Program (SHEP) trial, conducted between 1985 and 1990, antihypertensive therapy with chlorthalidone-based stepped-care therapy resulted in a lower rate of cardiovascular events than placebo but effects on mortality were not significant.