Prediction of Weight Loss and Regain Following Dietary, Lifestyle, and Pharmacologic Intervention

Prediction of Weight Loss and Regain Following Dietary, Lifestyle, and Pharmacologic Intervention

Por: A Napolitano, S R Miller, P R Murgatroyd, B Delafont, A Brooke, M Elkhawad, C Y Tan, S Virtue, A Vidal-Puig y D J Nunez. Clinical Pharmacology & Therapeutics (2012); 91 6, 1027–1034.

To develop statistical models for predicting weight loss and regain, we analyzed the phenotypic responses in an outpatient study of 60 obese subjects randomized to one of three 12-week interventions, diet (–600 kcal) alone, diet with exercise, and diet with sibutramine. This was followed by 12 weeks of observation.