Combination therapy of hypertension in the elderly: a subgroup analysis of the Combination of Olmesartan and a calcium channel blocker or diuretic in Japanese elderly hypertensive patients trial

La combinación de un ARA II (Olmesartan) y un anticálcico o un diuretico en ancianos japoneses,  demostro que los efectos en reducir el riesgo cardiovascular son similares, pero es   preferibles la combinacion de Olmesartan con un anticálcico

Por: Toshio Ogihara, Takao Saruta, Hiromi Rakugi, Ikuo Saito, Kazuaki Shimamoto, Hiroaki Matsuoka, Satoshi Teramukai, Jitsuo Higaki, Sadayoshi Ito y Kazuyuki Shimada for the COLM investigators.   Hypertension Research (2015) 38, 89–96.

Combination of OLMesartan and a calcium channel blocker or a diuretic in Japanese elderly hypertensive patients (COLM) trial demonstrated that olmesartan combinations with a CCB or diuretic have similar effects on reducing cardiovascular risk in elderly hypertensive patients. However, the safety profiles suggest that olmesartan combined with CCB may be preferable to olmesartan combined with diuretic. In this subgroup analysis, we further evaluated the effects and safety of these combinations in elderly (65–74 years old (y.o.)) and very elderly (75–84 y.o.) hypertensive patients.