The effect of antihypertensive drugs on chronic kidney disease: a comprehensive review

Por: Anastasia G Ptinopoulou, Maria I Pikilidou y Anastasios N Lasaridis.  Hypertension Research (2013) 36, 91–101.

Data from randomized clinical trials and epidemiological evidence identify systemic hypertension as the second most common modifiable risk factor for chronic kidney disease (CKD) progression after diabetes mellitus. CKD may progress silently over the years and early diagnosis and control of hypertension is of major importance in delaying renal function decline. Recent guidelines for the treatment of hypertension suggest the use of a variety of antihypertensive drugs in order to achieve the desired blood pressure levels. Renin–angiotensin system inhibitors have been undoubtedly studied the most and are suggested by guidelines and experts as first choice in patients with hypertension and renal injury, particularly in those with diabetes, as they have repeatedly shown to significantly reduce proteinuria. [Actualizado: 20 de mayo 2013]