Effect of tablets with a combination of telmisartan and amlodipine on patients with hypertension: the Cotalo study

Effect of tablets with a combination of telmisartan and amlodipine on patients with hypertension: the Cotalo study

Por: Mitsuru Ohishi, Tatsuo Kawai, Norihiro Hayashi, Shoichi Kitano, Tomohiro Katsuya, Masahiro Nagano, Atsushi Hirotani, Koichi Yamamoto, Kei Kamide y Hiromi Rakugi.  Hypertension Research (2013) 36, 620–626.

Fixed-dose combination (FDC) therapy with telmisartan 40 mg+amlodipine 5 mg (T40/A5) is expected to achieve tight blood pressure (BP) control because of the strong efficacy and long half-life of each drug. The aims of this study were to evaluate the 24-h antihypertensive efficacy of T40/A5 FDC therapy and to explore differences that may arise owing to different administration times in Japanese patients whose hypertension was not controlled by 5 mg of amlodipine per day. In this randomized clinical trial, 44 patients who had been taking amlodipine 5 mg per day and did not achieve their optimal BP target were enrolled (mean age: 67.8±10.2 years). [Actualizado: 24 de julio 2013]