Irbesartan, an angiotensin receptor blocker, exhibits metabolic, anti-inflammatory and antioxidative effects in patients with high-risk hypertension

Irbesartan, an angiotensin receptor blocker, exhibits metabolic, anti-inflammatory and antioxidative effects in patients with high-risk hypertension

Por: Isao Taguchi, Shigeru Toyoda, Kazuhiko Takano, Takuo Arikawa, Migaku Kikuchi, Mikie Ogawa, Shichiro Abe, Koichi Node yTeruo Inoue.  Hypertension Research (2013) 36, 608–613.

Irbesartan, an angiotensin II receptor blocker (ARB), acts as a selective PPAR-? (peroxisome proliferator-activated receptor-?) modulator, and thus may have anti-inflammatory and antioxidative effects, as well as beneficial effects on glucose and lipid metabolism. We enrolled 118 high-risk hypertensive outpatients, defined as those with the presence of at least one complication such as coronary artery disease, cerebrovascular disease or diabetes, and who were receiving any ARB except for irbesartan (67±10 years, 80% male subjects). [Actualizado: 8 de julio de 2013]