Long-term safety and efficacy of telmisartan/amlodipine single pill combination in the treatment of hypertension

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Long-term safety and efficacy of telmisartan/amlodipine single pill combination in the treatment of hypertension

Por: Scott S Billecke y Pamela A Marcovitz.  DOVE MEDICAL March 2013, Volume 2013:9 Pages 95 – 104.

The use of multiple drug regimens is increasingly recognized as a tacit requirement for the management of hypertension, a necessity fueled in part by rising rates of metabolic syndrome and diabetes. By targeting complementary pathways, combinations of antihypertensive drugs can be applied to provide effective blood pressure control while minimizing side effects and reducing exposure to high doses of individual medications. In addition, combination therapies, including angiotensin converting enzyme (ACE) inhibitors and calcium channel blockers (CCBs), have the added benefit of reducing cardiovascular mortality and morbidity over other dual therapies while providing equivalent blood pressure control. It is possible that angiotensin receptor blockers (ARBs), which unlike ACE inhibitors are minimally affected by upregulation of alternative pathways for angiotensin II accumulation following long-term treatment, would also provide such outcome benefits.  [Actualizado: 25 de abril 2013].