How important is it to control nocturnal hypertension with angiotensin II type 1 receptor blockers?

Esta sección expone trabajos actuales, de carácter investigativo sobre la hipertensión arterial.

How important is it to control nocturnal hypertension with angiotensin II type 1 receptor blockers?

Por: Shin-ichiro Miura y Keijiro Saku.  Hypertension Research (2013) 36, 194–195.

Better blood pressure (BP) control is associated with remarkable clinical benefits with regard to cardiovascular (CV) and renal protection. Patients with chronic kidney disease (CKD) are at significantly higher risk of CV disease (CVD),1 and patients with overt proteinuria as well as albuminuria without a reduction in the estimated glomerular filtration rate (eGFR) are also at significantly higher risk.1 In addition, proteinuria or albuminuria itself should be a target for reducing hard end points. Angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) are highly selective for the AT1 receptor and block the deleterious effects of Ang II.2 ARBs clearly decrease proteinuria and protect the kidneys.3 A nocturnal increase in BP on ambulatory monitoring is superior to office BP for predicting a worsening of albuminuria in elderly individuals with type 2 diabetes.  [Actualizado: 11 de marzo 2013]