Brain renin–angiotensin system in the nexus of hypertension and aging

Brain renin–angiotensin system in the nexus of hypertension and aging

Por: Amy C Arnold, Patricia E Gallagher y Debra I Diz.  Hypertension Research (2013) 36, 5–13

Aging is associated with an imbalance in sympathetic and parasympathetic outflow to cardiovascular effector organs.
This autonomic imbalance contributes to the decline in cardiovagal baroreceptor reflex function during aging, which allows for unrestrained activation of the sympathetic nervous system to negatively impact resting systolic blood pressure and its variability. Further, impaired baroreflex function can contribute to the development of insulin resistance and other features of the metabolic syndrome during aging through overlap in autonomic neural pathways that regulate both cardiovascular and metabolic functions.  [publicada: 23 de enero de enero 2013]