Managing kidney disease with blood-pressure control

Por: Elke Wühl and Franz Schaefer.  Nat. Rev. Nephrol. 7, 434–444 (2011).

The progression of chronic kidney disease (CKD) is largely independent of the underlying kidney disorder once renal function has fallen below a critical level. Hypertension is an independent risk factor for disease progression in both adult and pediatric patients with kidney disorders. Increasing evidence from clinical trials indicates that the rate of CKD progression can be lowered by pharmacological interventions. Nephroprotective strategies currently focus on the blockade of the renin–angiotensin system.