Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension

Aortic Stiffness, Blood Pressure Progression, and Incident Hypertension

Por: Bernhard M. Kaess, MD; Jian Rong, PhD; Martin G. Larson, ScD; Naomi M. Hamburg, MD; Joseph A. Vita, MD; Daniel Levy, MD; Emelia J. Benjamin, MD, ScM; Ramachandran S. Vasan, MD y Gary F. Mitchell, MD.  JAMA. 2012;308(9):875-881.

Vascular stiffness increases with advancing age and is a major risk factor for age-related morbidity and mortality. Vascular stiffness and blood pressure pulsatility are related; however, temporal relationships between vascular stiffening and blood pressure elevation have not been fully delineated.  To examine temporal relationships among vascular stiffness, central hemodynamics, microvascular function, and blood pressure progression. In this cohort, higher aortic stiffness, FWA, and augmentation index were associated with higher risk of incident hypertension; however, initial blood pressure was not independently associated with risk of progressive aortic stiffening.