Significance of estimated salt excretion as a possible predictor of the efficacy of concomitant angiotensin receptor blocker (ARB) and low-dose thiazide in patients with ARB resistance

Significance of estimated salt excretion as a possible predictor of the efficacy of concomitant angiotensin receptor blocker (ARB) and low-dose thiazide in patients with ARB resistance

Por: Hajime Hasegawa, Koichi Kanozawa, Juko Asakura, Kaori Takayanagi, Osamu Komuro, Hiroyuki Fukada, Hidetsugu Tokushima, Hisaya Kogure, Masatoshi Matsuzawa y Tetsuya Mitarai.  Hypertension Research (2013) 36, 776–782.

The purpose of this study was to assess the factors affecting the efficacy of combination therapy with losartan and thiazide, with a focus on the significance of salt excretion, via a multicenter observational study. Adult patients with essential hypertension showing therapy resistance to angiotensin receptor blocker (ARB) as a monotherapy or in combination with Ca channel blockers (CCB) were enrolled, and their previously administered ARBs were replaced with the combination tablet containing losartan (50 mg per day) and hydrochlorothiazide (12.5 mg per day). Blood pressure and biochemical parameters were monitored for a year.   [Actualizado: 06 septiembre 2013].