Hunting for genes for hypertension: the Millennium Genome Project for Hypertension

Hunting for genes for hypertension: the Millennium Genome Project for Hypertension

Por: Yasuharu Tabara, Katsuhiko Kohara y Tetsuro Miki on behalf of the study group of the Millennium Genome Project for Hypertension.   Hypertension Research (2012) 35, 567–573.

The Millennium Genome Project for Hypertension was started in 2000 to identify genetic variants conferring susceptibility to hypertension, with the aim of furthering the understanding of the pathogenesis of this condition and realizing genome-based personalized medical care. Two different approaches were launched, genome-wide association analysis using single-nucleotide polymorphisms (SNPs) and microsatellite markers, and systematic candidate gene analysis, under the hypothesis that common variants have an important role in the etiology of common diseases. These multilateral approaches identified ATP2B1 as a gene responsible for hypertension in not only Japanese but also Caucasians. The high blood pressure susceptibility conferred by certain alleles of ATP2B1 has been widely replicated in various populations. [Actualizado: 22 de agosto 2013].