A Possible Interaction Between Systemic and Renal Angiotensinogen in the Control of Blood Pressure

A Possible Interaction Between Systemic and Renal Angiotensinogen in the Control of Blood Pressure

Por: Nirupama Ramkumar, Deborah Stuart, Jian Ying y Donald E. Kohan.  American Journal of Hypertension, Volume 26, Issue 4, Pp. 473-480.

Angiotensinogen (AGT) is synthesized in the liver and proximal tubule. AGT overexpression at either site might increase blood pressure (BP). We used transgenic mice with AGT overexpression in proximal tubule (K), liver (L), or both sites (KL) to determine the relative contributions of hepatic- and proximal tubule–derived AGT in modulating BP.  Mice with liver AGT overexpression manifest salt-sensitive hypertension, whereas mice with renal AGT overexpression are hypertensive regardless of salt intake. Systemic AGT may stimulate endogenous renal AGT synthesis during high sodium intake, leading to hypertension in L mice.  [Actualizado: 3 de junio 2013]