Predictors of plasma and urinary catecholamine levels in normotensive and hypertensive men and women

Por: A R Saxena, B Chamarthi, G H Williams, P N Hopkins y E W Seely.  Journal of Human Hypertension (2014) 28, 292–297.

Age, sex, hypertension and dietary sodium are proposed to affect plasma and urinary catecholamines. Yet no prior study has examined the simultaneous effects of these factors within the same study population. So results may have been confounded by factors not determined. We investigate, for the first time, the impact of simultaneously determined predictors of plasma and urinary catecholamines and the relationship of catecholamines with the diagnosis of hypertension. Hypertensive and normotensive subjects (n=308) were studied off antihypertensives in liberal and low sodium balance. 24?h urinary catecholamines (norepinephrine and epinephrine) were measured. Plasma catecholamines were measured supine after overnight fast.

The evidence for treating hypertension in older people with dementia: a systematic review

Por: L C Beishon, J K Harrison, R H Harwood, T G Robinson, J R F Gladman y S P Conroy.  Journal of Human Hypertension (2014) 28, 283–287.

Hypertension and dementia commonly co-exist in older people, yet guidance is lacking on how to manage these co-existing conditions. The aim of this systematic review was to assess the evidence for the treatment of hypertension in older people with dementia. Medline, EMBASE, Cochrane Library and the national research register archives were searched. Inclusion criteria were: randomised controlled trial of hypertension treatment, included participants aged 65+ years, participants had a diagnosis of dementia (global cognitive decline for at least 6 months affecting daily function), and the study assessed cognitive outcomes using validated tools.