17/02/2014

Blood pressure changes after renal denervation at 10 European expert centers

feb 17th, 2014. En: Propuestas del editor.

Por: A Persu, Y Jin, M Azizi, M Baelen, S Völz, A Elvan, F Severino, J Rosa, A Adiyaman, F E Fadl Elmula, A Taylor, A Pechère-Bertschi, G Wuerzner, F Jokhaji, T Kahan, J Renkin, M Monge4, P Widimský, L Jacobs, M Burnier, P B Mark, S E Kjeldsen, B Andersson, M Sapoval y J A Staessen, on behalf of the European Network COordinating research on Renal Denervation (ENCOReD). Journal of Human Hypertension (2014) 28, 150–156.

We did a subject-level meta-analysis of the changes (Δ) in blood pressure (BP) observed 3 and 6 months after renal denervation (RDN) at 10 European centers. Recruited patients (n=109; 46.8% women; mean age 58.2 years) had essential hypertension confirmed by ambulatory BP. From baseline to 6 months, treatment score declined slightly from 4.7 to 4.4 drugs per day. Systolic/diastolic BP fell by 17.6/7.1 mm Hg for office BP, and by 5.9/3.5, 6.2/3.4, and 4.4/2.5 mm Hg for 24-h, daytime and nighttime BP (Pless than or equal to0.03 for all). In 47 patients with 3- and 6-month ambulatory measurements, systolic BP did not change between these two time points (Pgreater than or equal to0.08).