Salt, the renin–angiotensin–aldosterone system and resistant hypertension
Por: Tatsuo Shimosawa. Hypertension Research (2013) 36, 657–660.
High salt intake is a risk for developing resistant hypertension, and even under triple therapy with diuretics, an angiotensin-converting enzyme inhibitor/angiotensin receptor blocker and a calcium channel blocker, the volume is occasionally not controlled. In such cases, a mineralocorticoid receptor (MR) antagonist additively lowers the circulating blood volume and blood pressure despite the lower circulating aldosterone level. This mechanism may be explained by the increase in the number of MR under some conditions or the activation of these receptors independent of aldosterone.
En esta sección les exponemos algunos artículos publicados sobre la hipertensión arterial.
De la Revista: American Journal of Hypertension
Por: Diana Chin, Allegra Battistoni, Giuliano Tocci, Jasmine Passerini, Gianfranco Parati y Massimo Volpe. Am J Hypertens (2012) 25 (12): 1226-1235.
Por: Gabriel Coll-de-Tuero, Marc Saez, Carmen Roca-Saumell, Antonio Rodriguez-Poncelas, Pilar Franco, Antoni Dalfó, Laia Calvó-Perxas, Antonio Pose-Reino y Joan Bayó-Llibre. Am J Hypertens (2012) 25 (12): 1256-1263.
Abdominal Obesity, Body Mass Index, and Hypertension in US Adults: NHANES 2007–2010
Por: Yechiam Ostchega, Jeffery P. Hughes, Ana Terry, Tala H.I. Fakhouri y Ivey Miller. Am J Hypertens (2012) 25 (12): 1271-1278.
Por: Cécilia Cacciolati, Christophe Tzourio, Carole Dufouil, Annick Alpérovitch y Olivier Hanon. Am J Hypertens (2012) 25 (12): 1279-1285.
Cost-Effectiveness of Renin-Guided Treatment of Hypertension
Por: Steven M. Smith y Jonathan D. Campbell. American Journal of Hypertension, volume 26, Issue 11, pp. 1303-1310.
A plasma renin activity (PRA)–guided strategy is more effective than standard care in treating hypertension (HTN). However, its clinical implementation has been slow, presumably due in part to economic concerns. We estimated the cost effectiveness of a PRA-guided treatment strategy compared with standard care in a treated but uncontrolled HTN population. Our results suggest that PRA-guided therapy compared with standard care increases QALYs and medical costs in most scenarios. PRA-guided therapy appears to be most cost effective in younger persons and those with more cardiovascular risk factors.
En esta sección les exponemos algunos artículos publicados sobre la hipertensión arterial.
De la Revista: American Journal of Hypertension (Sobre la sal)
Por: Theodore A. Kotchen. Am J Hypertens (2013) 26 (10), 1177.
Sodium Reduction Is a Public Health Priority: Reflections on the Institute of Medicine’s Report, Sodium Intake in Populations: Assessment of Evidence
http://ajh.oxfordjournals.org/content/26/10/1178.full
Por: Janelle P. Gunn, Jessica L. Barron, Barbara A. Bowman, Robert K. Merritt, Mary E. Cogswell, Sonia Y. Angell, Ursula E. Bauer y Thomas R. Frieden. Am J Hypertens (2013) 26 (10): 1178-1180.
Getting the Message Right: Reducing Sodium Intake Saves Lives
Por: Jenifer E. Clapp, Christine J. Curtis, Susan M. Kansagra y Thomas A. Farley. Am J Hypertens (2013) 26 (10): 1181-1182.
Extreme Sodium Reductions for the Entire Population: Zealotry or Evidence Based?
Por: Andrew Mente, Martin J. O’Donnell y Salim Yusuf. Am J Hypertens (2013) 26 (10): 1187-1190.
Por: Lawrence J. Appel y Paul K. Whelton. Am J Hypertens (2013) 26 (10): 1183-1186.
Sodium: How and How Not to Set a Nutrient Intake Recommendation
Por: Robert P. Heaney. Am J Hypertens (2013) 26 (10): 1194-1197.
Por: N C Barengo, R Antikainen, M Kastarinen, T Laatikainen y J Tuomilehto. Journal of Human Hypertension (2013) 27, 693–697.
he objective of this study (follow-up of 26 113 people) was to investigate differences in the risk of cardiovascular disease (CVD) and all-cause mortality among hypertensive people according to the control of systolic blood pressure (SBP) and diastolic blood pressure (DBP). People with a history of coronary heart disease, heart failure, cancer or incomplete data at baseline (n=1113) were excluded from the study. The participants were classified into six groups according to their blood pressure status. In conclusion, our results strengthen the evidence that uncontrolled SBP alone and uncontrolled DBP alone are risk factors of all-cause and CVD mortality.
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