Salt, the renin–angiotensin–aldosterone system and resistant hypertension

Salt, the renin–angiotensin–aldosterone system and resistant hypertension

Por: Tatsuo Shimosawa.  Hypertension Research (2013) 36, 657–660.

High salt intake is a risk for developing resistant hypertension, and even under triple therapy with diuretics, an angiotensin-converting enzyme inhibitor/angiotensin receptor blocker and a calcium channel blocker, the volume is occasionally not controlled. In such cases, a mineralocorticoid receptor (MR) antagonist additively lowers the circulating blood volume and blood pressure despite the lower circulating aldosterone level. This mechanism may be explained by the increase in the number of MR under some conditions or the activation of these receptors independent of aldosterone.