Ethnic differences in genetic predisposition to hypertension

Estudios importantes sobre hipertension arterial de Cuba y el mundo

Ethnic differences in genetic predisposition to hypertension

Por: Norihiro Kato.  Hypertension Research (2012) 35, 574–581.

Recently, large-scale meta-analyses of genome-wide association (GWA) studies have identified a number of loci significantly associated with systolic and/or diastolic blood pressure (BP). Most of the GWA studies reported to date were conducted in populations of European descent. Given the appreciable ethnic differences in clinical presentation of hypertension, studies in non-European populations allow us to assess the relevance of the findings in Europeans to other ethnic groups and to potentially discover novel variants. Before the GWA scan era, the presence of racial or ethnic differences has been widely recognized for response to antihypertensive therapies, salt sensitivity and impact of obesity on developing hypertension.  [Actualizado: 22 de agosto 2013].