Estudios importantes sobre hipertension arterial de Cuba y el mundo

Ethnic differences in genetic predisposition to hypertension

Por: Norihiro Kato.  Hypertension Research (2012) 35, 574–581.

Recently, large-scale meta-analyses of genome-wide association (GWA) studies have identified a number of loci significantly associated with systolic and/or diastolic blood pressure (BP). Most of the GWA studies reported to date were conducted in populations of European descent. Given the appreciable ethnic differences in clinical presentation of hypertension, studies in non-European populations allow us to assess the relevance of the findings in Europeans to other ethnic groups and to potentially discover novel variants. Before the GWA scan era, the presence of racial or ethnic differences has been widely recognized for response to antihypertensive therapies, salt sensitivity and impact of obesity on developing hypertension.  [Actualizado: 22 de agosto 2013].

Hunting for genes for hypertension: the Millennium Genome Project for Hypertension

Por: Yasuharu Tabara, Katsuhiko Kohara y Tetsuro Miki on behalf of the study group of the Millennium Genome Project for Hypertension.   Hypertension Research (2012) 35, 567–573.

The Millennium Genome Project for Hypertension was started in 2000 to identify genetic variants conferring susceptibility to hypertension, with the aim of furthering the understanding of the pathogenesis of this condition and realizing genome-based personalized medical care. Two different approaches were launched, genome-wide association analysis using single-nucleotide polymorphisms (SNPs) and microsatellite markers, and systematic candidate gene analysis, under the hypothesis that common variants have an important role in the etiology of common diseases. These multilateral approaches identified ATP2B1 as a gene responsible for hypertension in not only Japanese but also Caucasians. The high blood pressure susceptibility conferred by certain alleles of ATP2B1 has been widely replicated in various populations. [Actualizado: 22 de agosto 2013].

Artículos sobre Genética e hipertensión arterial.

Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse.

Por: Majid Nikpay, Ondrej Šeda, Johanne Tremblay, Milan Petrovich, Daniel Gaudet, Theodore A Kotchen, Allen W Cowley Jr y Pavel Hamet.   Hypertension Research (2012) 35, 585–591.

β-Adrenergic receptor gene polymorphism is a genetic risk factor for cardiovascular disease: a cohort study with hypertensive patients.

Por: Yoshihiro Iwamoto, Mitsuru Ohishi, Ming Yuan, Yuji Tatara, Nozomi Kato, Yasushi Takeya, Miyuki Onishi, Yoshihiro Maekawa, Kei Kamide and Hiromi Rakugi.  Hypertens Res 34: 294-295; January 20, 2011.

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.

Por: Norihiro Kato, Fumihiko Takeuchi, Yasuharu Tabara, Tanika N Kelly, Min Jin Go, Xueling Sim, Wan Ting Tay, et al. Nature Genetics 43, 531–538, (2011).

Mapping genetic determinants of kidney damage in rat models.

Por: Angela Schulz y Reinhold Kreutz.  Hypertens Res 35: 675-694; May 31, 2012.

Marcadores genéticos en hipertensión esencial

Por: Cristóbal  Passalacqua y Silvia Castillo Taucher.  Rev. méd. Chile v.138 n.6 Santiago jun. 2010.