Intensive Blood Pressure Lowering Increases Cerebral Blood Flow in Older Subjects With Hypertension

Intensive Blood Pressure Lowering Increases Cerebral Blood Flow in Older Subjects With Hypertension

Por: Dinesh Tryambake, Jiabao He, Michael J. Firbank,  John T. O’Brien, Andrew M. Blamire y Gary A. Ford.  Hypertension. 2013; 61: 1309-1315.

Hypertension is associated with reduced cerebral blood flow (CBF). Intensive (<130/80 mm Hg) blood pressure (BP) lowering in older people might give greater reduction in cardiovascular risk, but there are concerns that this might produce hypoperfusion which may precipitate falls and possibly stroke.
This study demonstrates that intensive BP treatment to <130/80 mm Hg with a calcium channel and angiotensin-converting enzyme inhibitor–based regimen in older people with hypertension increases CBF. This finding, consistent with previous observational studies, suggests that intensive BP lowering might protect the aging brain from leukoaraiosis and brain atrophy, which may be related to hypoperfusion.
[Actualizado: 28 de junio 2013]