Plasma Total Testosterone and Incident Cardiovascular Events in Hypertensive Patients

Plasma Total Testosterone and Incident Cardiovascular Events in Hypertensive Patients

Por: Charalambos Vlachopoulos, Nikolaos Ioakeimidis,  Dimitrios Terentes-Printzios, Konstantinos Aznaouridis, Konstantinos Rokkas, Athanassios Aggelis, Alexandros Synodinos, George Lazaros y Christodoulos Stefanadis.  American Journal of Hypertension, volume 26, Issue 3, pp. 373-381.

Androgen deficiency confers an independent risk for cardiovascular events and total mortality. Hypertension, a major contributory factor to the development of cardiovascular disease, has also been associated with increased prevalence of low testosterone. We investigated whether low androgen concentration predicts incident major adverse cardiovascular events (MACE) in middle-aged nondiabetic hypertensive patients without clinical atherosclerosis. Our results show that low plasma testosterone is associated with increased risk for a MACE in hypertensive patients. Low endogenous androgen concentration improves risk prediction when added to standard risk factors and may represent a valuable biomarker of prediction of cardiovascular disease risk in these patients. [Actualizado: 26 de febrero de 2013].