Renoprotective and antioxidant effects of cilnidipine in hypertensive patients

La sección Investigaciones expone trabajos actuales, de carácter investigativo sobre la hipertensión arterial.

Renoprotective and antioxidant effects of cilnidipine in hypertensive patients

Por: Takeshi Soeki, Mitsuhiro Kitani, Kenya Kusunose, Shusuke Yagi, Yoshio Taketani, Kunihiko Koshiba, Tetsuzo Wakatsuki, Shunsuke Orino, Kazuhiro Kawano y Masataka Sata.  Hypertens Res 35: 1058-1062; July 5, 2012.

Cilnidipine, an L/N-type calcium channel blocker (CCB), has been reported to have more beneficial effects on proteinuria progression in hypertensive patients than amlodipine, an L-type CCB. The N-type calcium channel blockade that inhibits renal sympathetic nerve activity might reduce glomerular hypertension by facilitating vasodilation of the efferent arterioles. However, the precise mechanism of the renoprotective effect of cilnidipine remains unknown. [publicado: 4 de diciembre 2012.]