Association of adipokines with blood pressure in rural Chinese adolescents

Association of adipokines with blood pressure in rural Chinese adolescents

Por: H Wang, J Necheles, J S Birne1, Z Li, H Xing, G Tang, K K Christoffel, W J Brickman, D Zimmerman y X Wang. Journal of Human Hypertension (2012) 26, 493–501.

Previous research has demonstrated that adipokines influence blood pressure (BP). Limited data exist in healthy adolescents, who are in a critical period for preventing the development of high BP. This study investigated the association of leptin, adiponectin and the leptin-to-adiponectin ratio (LAR) with BP in rural Chinese adolescents. This report included 1245 adolescents (average body mass index: 19.3 kg m−2) aged 13–21 years from an established twin cohort. We examined gender-specific associations between plasma adipokines and BP, with adjustment for measures of adiposity and insulin resistance (IR). We estimated the genetic contribution to adipokines using the twin design and Cholesky decomposition models.