Evalúan candidatos vacunales de DNA contra la Influenza Porcina

Inovio Biomedical Corporation, un lider en el diseño, desarrollo y distribución de vacunas DNA, anunció que había establecido una nueva colaboración con el Laboratorio Nacional de Microbiología de la Agencia de Salud Pública de Canadá y la Universidad de Pensilvania para una ulterior de la vacuna Inovio DNA contra el virus de la influenza porcina A H1N1. Como parte de su programa universal para vacunas contra la influenza, Inovio ha diseñado y producido vacunas consenso de DNA contra cepas de influenza H1N1.Estas vacunas consenso, distribuidas empleando la tecnología de electroporación patentada por Inovio, tienen el potencial de brindar protección contra un amplio espectro de cepas de influenza existentes así como otras no aun identificadas que pudieran surgir, uno de los retos permanentes al tratar de proteger contra la influenza. El propósito de esta colaboración es probar estos candidatos vacunales contra las cepas de las influenzas estacional y pandémica en modelos animales e incluirá el estudio contra la cepa de H1N1 porcina recientemente identificada.

http://www.medicalnewstoday.com/articles/155941.php

The World Health Organization’s (WHO) upgrade on June 11, 2009, of the “swine flu” to a full pandemic status acknowledged the detection of the virus in 74 countries. This first declaration of a global pandemic since 1968 reflected more the rate and ease of spread rather than virulence of the virus. Significantly, by early June scientists had characterized over 60 different gene sequences of the swine influenza A (H1N1) virus amongst the first 259 samples isolated from humans. The rapid spread and evolution of this virus highlights the great potential risk should a more virulent strain of the virus emerge.

While strain-specific vaccines may provide some protective immunity against a known influenza strain, they do not resolve the fundamental challenge to protecting against influenza, which is the virus’ constant evolution beyond the protective capabilities of strain-specific vaccines. Unfortunately, even the relatively short period of six to nine months to launch a new strain-specific vaccine could allow a more virulent influenza strain to rapidly spread and potentially wreak significant havoc.

“We believe a consensus vaccine approach is imperative and look forward to continuing our collaborative evaluation of Inovio’s novel DNA vaccines with their ability to provide protection against evolving, unmatched influenza strains,” said Dr. David B. Weiner, Professor, Dept. of Pathology & Laboratory Medicine, University of Pennsylvania and Chairman of Inovio’s Scientific Advisory Board.

Dr. J. Joseph Kim, Inovio’s CEO, stated, “The current swine flu outbreak highlights the fact that the world cannot rely solely on the `catch-up’ strategy of influenza vaccine design. We need vaccines that provide at least some broad protective capability against evolving seasonal influenza strains and those with pandemic potential. We have already achieved significant validating data in large animal models regarding the ability of Inovio’s consensus vaccines to protect against unmatched strains of different influenza sub-types and look forward to the data resulting from this collaboration of vaccine experts.”

Work completed by Dr. Gary Kobinger, Head, Vector Design and Immunotherapy, Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada, and his colleagues recently resulted in the characterization of several currently-circulating clinical isolates of the swine-like H1N1 virus.

Inovio, the National Microbiology Laboratory of the Public Health Agency of Canada, and the University of Pennsylvania have previously collaborated and published on studies involving Inovio’s consensus DNA vaccines. In a study of Inovio’s VGX-3400, ferrets vaccinated with this H5N1 avian flu vaccine candidate, when challenged with the unmatched “bird flu” A/Vietnam/1203/04 strain, showed 100% protection.

In another study, mice immunized with an Inovio H1N1 consensus DNA vaccine were then challenged with a lethal dose of the unmatched H1N1 virus that caused the 1918 Spanish flu, which killed over 40 million people. All the immunized mice survived the challenge (100% protection) to the end of the experiment and displayed significant protection from infection-associated morbidity. All the control mice died by day 8 after being challenged with the virus.

Inovio’s influenza vaccine constructs were designed using the company’s novel SynCon™ technology, which facilitates the design of DNA-based vaccines capable of protecting against unmatched sub-types and strains of pathogens. Inovio scientists have created DNA vaccine candidates broadly targeting the H1N1, H2N2, H3N2, and H5N1 influenza sub-types, which make up the majority of seasonal and pandemic influenza. By formulating combinations of these individual component vaccines, Inovio can employ this designer approach to rapidly develop universal influenza vaccines potentially capable of targeting multiple influenza sub-types and able to protect against evolving strains of the virus.